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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The role of heparan sulfate deficiency in autistic phenotype: potential involvement of Slit/Robo/srGAPs-mediated dendritic spine formation
|
|---|---|
| Published in |
Neural Development, April 2016
|
| DOI | 10.1186/s13064-016-0066-x |
| Pubmed ID | |
| Authors |
Christine Pérez, Darrell Sawmiller, Jun Tan |
| Abstract |
Autism Spectrum Disorders (ASD) are the second most common developmental cause of disability in the United States. ASDs are accompanied with substantial economic and emotional cost. The brains of ASD patients have marked structural abnormalities, in the form of increased dendritic spines and decreased long distance connections. These structural differences may be due to deficiencies in Heparin Sulfate (HS), a proteoglycan involved in a variety of neurodevelopmental processes. Of particular interest is its role in the Slit/Robo pathway. The Slit/Robo pathway is known to be involved in the regulation of axonal guidance and dendritic spine formation. HS mediates the Slit/Robo interaction; without its presence Slit's repulsive activity is abrogated. Slit/Robo regulates dendritic spine formation through its interaction with srGAPs (slit-robo GTPase Activating Proteins), which leads to downstream signaling, actin cytoskeleton depolymerization and dendritic spine collapse. Through interference with this pathway, HS deficiency can lead to excess spine formation. |
X Demographics
The data shown below were collected from the profiles of 67 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 26 | 39% |
| United Kingdom | 4 | 6% |
| Kenya | 1 | 1% |
| Spain | 1 | 1% |
| Peru | 1 | 1% |
| Armenia | 1 | 1% |
| Switzerland | 1 | 1% |
| France | 1 | 1% |
| India | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 28 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 63 | 94% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
| Practitioners (doctors, other healthcare professionals) | 1 | 1% |
| Scientists | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 2% |
| Unknown | 55 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 13% |
| Student > Master | 7 | 13% |
| Student > Doctoral Student | 7 | 13% |
| Researcher | 6 | 11% |
| Professor | 4 | 7% |
| Other | 8 | 14% |
| Unknown | 17 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 18% |
| Medicine and Dentistry | 8 | 14% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Agricultural and Biological Sciences | 3 | 5% |
| Psychology | 3 | 5% |
| Other | 9 | 16% |
| Unknown | 19 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 52. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2023.
All research outputs
#825,635
of 25,654,806 outputs
Outputs from Neural Development
#5
of 233 outputs
Outputs of similar age
#14,433
of 314,188 outputs
Outputs of similar age from Neural Development
#1
of 6 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 233 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,188 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them