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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease
|
|---|---|
| Published in |
Molecular Neurodegeneration, April 2012
|
| DOI | 10.1186/1750-1326-7-12 |
| Pubmed ID | |
| Authors |
Miriam A Hickey, Chunni Zhu, Vera Medvedeva, Renata P Lerner, Stefano Patassini, Nicholas R Franich, Panchanan Maiti, Sally A Frautschy, Scott Zeitlin, Michael S Levine, Marie-Françoise Chesselet |
| Abstract |
No disease modifying treatment currently exists for Huntington's disease (HD), a fatal neurodegenerative disorder characterized by the formation of amyloid-like aggregates of the mutated huntingtin protein. Curcumin is a naturally occurring polyphenolic compound with Congo red-like amyloid binding properties and the ability to cross the blood brain barrier. CAG140 mice, a knock-in (KI) mouse model of HD, display abnormal aggregates of mutant huntingtin and striatal transcriptional deficits, as well as early motor, cognitive and affective abnormalities, many months prior to exhibiting spontaneous gait deficits, decreased striatal volume, and neuronal loss. We have examined the ability of life-long dietary curcumin to improve the early pathological phenotype of CAG140 mice. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| United Kingdom | 2 | 1% |
| Austria | 1 | <1% |
| Netherlands | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 141 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 15% |
| Researcher | 20 | 13% |
| Student > Master | 20 | 13% |
| Student > Bachelor | 18 | 12% |
| Other | 7 | 5% |
| Other | 19 | 13% |
| Unknown | 42 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 23 | 15% |
| Medicine and Dentistry | 16 | 11% |
| Neuroscience | 16 | 11% |
| Biochemistry, Genetics and Molecular Biology | 13 | 9% |
| Psychology | 7 | 5% |
| Other | 29 | 19% |
| Unknown | 45 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2016.
All research outputs
#12,853,669
of 22,664,267 outputs
Outputs from Molecular Neurodegeneration
#638
of 842 outputs
Outputs of similar age
#86,452
of 161,215 outputs
Outputs of similar age from Molecular Neurodegeneration
#3
of 12 outputs
Altmetric has tracked 22,664,267 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 842 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 161,215 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.