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Riluzole neuroprotection in a parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation

Overview of attention for article published in BMC Neuroscience, April 2012
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Title
Riluzole neuroprotection in a parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation
Published in
BMC Neuroscience, April 2012
DOI 10.1186/1471-2202-13-38
Pubmed ID
Authors

Marica Carbone, Susan Duty, Marcus Rattray

Abstract

Riluzole is a neuroprotective drug used in the treatment of motor neurone disease. Recent evidence suggests that riluzole can up-regulate the expression and activity of the astrocyte glutamate transporter, GLT-1. Given that regulation of glutamate transport is predicted to be neuroprotective in Parkinson's disease, we tested the effect of riluzole in parkinsonian rats which had received a unilateral 6-hydroxydopamine injection into the median forebrain bundle.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 2%
Australia 1 2%
Unknown 57 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 25%
Student > Master 11 19%
Researcher 10 17%
Professor > Associate Professor 5 8%
Student > Bachelor 3 5%
Other 10 17%
Unknown 5 8%
Readers by discipline Count As %
Neuroscience 15 25%
Agricultural and Biological Sciences 14 24%
Medicine and Dentistry 8 14%
Pharmacology, Toxicology and Pharmaceutical Science 5 8%
Biochemistry, Genetics and Molecular Biology 3 5%
Other 7 12%
Unknown 7 12%