Title |
Enhancing pathogen identification in patients with meningitis and a negative Gram stain using the BioFire FilmArray® Meningitis/Encephalitis panel
|
---|---|
Published in |
Annals of Clinical Microbiology and Antimicrobials, April 2016
|
DOI | 10.1186/s12941-016-0137-1 |
Pubmed ID | |
Authors |
Susan H. Wootton, Elizabeth Aguilera, Lucrecia Salazar, Andrew C. Hemmert, Rodrigo Hasbun |
Abstract |
Meningitis with a negative cerebrospinal (CSF) Gram stain represents a diagnostic and therapeutic challenge. The purpose of our study was to evaluate the performance of the BioFire FilmArray(®) Meningitis/Encephalitis (FA ME) panel in patients presenting with community-acquired meningitis with a negative Gram stain. CSF from 48 patients with community-acquired meningitis with a negative Gram stain admitted to four hospitals in Houston, TX underwent additional testing by the FA ME. FA ME results were compared to results obtained as part of routine evaluation. The panel detected pathogens not previously identified in 11 (22.9 %) of 48, but did not detect pathogens identified by standard technique (West Nile virus, Histoplasma) in 5 (15.2 %) patients. Rapid testing for the most common pathogens causing meningitis will aid in the diagnosis and treatment of patients with meningitis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 20% |
Australia | 1 | 20% |
United States | 1 | 20% |
Venezuela, Bolivarian Republic of | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Scientists | 1 | 20% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 102 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 15% |
Student > Bachelor | 11 | 11% |
Student > Ph. D. Student | 10 | 10% |
Other | 9 | 9% |
Student > Master | 9 | 9% |
Other | 22 | 22% |
Unknown | 26 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 36 | 35% |
Biochemistry, Genetics and Molecular Biology | 14 | 14% |
Immunology and Microbiology | 6 | 6% |
Agricultural and Biological Sciences | 5 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 5 | 5% |
Unknown | 33 | 32% |