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Relevance of internal time and circadian robustness for cancer patients

Overview of attention for article published in BMC Cancer, April 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

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Title
Relevance of internal time and circadian robustness for cancer patients
Published in
BMC Cancer, April 2016
DOI 10.1186/s12885-016-2319-9
Pubmed ID
Authors

Elisabet Ortiz-Tudela, Pasquale F. Innominato, Maria Angeles Rol, Francis Lévi, Juan Antonio Madrid

Abstract

Adequate circadian timing of cancer treatment schedules (chronotherapy) can enhance tolerance and efficacy several-fold in experimental and clinical situations. However, the optimal timing varies according to sex, genetic background and lifestyle. Here, we compute the individual phase of the Circadian Timing System to decipher the internal timing of each patient and find the optimal treatment timing. Twenty-four patients (11 male; 13 female), aged 36 to 77 years, with advanced or metastatic gastro-intestinal cancer were recruited. Inner wrist surface Temperature, arm Activity and Position (TAP) were recorded every 10 min for 12 days, divided into three 4-day spans before, during and after a course of a set chronotherapy schedule. Pertinent indexes, I < O and a new biomarker, DI (degree of temporal internal order maintenance), were computed for each patient and period. Three circadian rhythms and the TAP rhythm grew less stable and more fragmented in response to treatment. Furthermore, large inter- and intra-individual changes were found for T, A, P and TAP patterns, with phase differences of up to 12 hours among patients. A moderate perturbation of temporal internal order was observed, but the administration of fixed chronomodulated chemotherapy partially resynchronized temperature and activity rhythms by the end of the study. The integrated variable TAP, together with the asynchrony among rhythms revealed by the new biomarker DI, would help in the personalization of cancer chronotherapy, taking into account individual circadian phase markers.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 79 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 15 19%
Student > Ph. D. Student 12 15%
Researcher 10 13%
Student > Master 10 13%
Student > Doctoral Student 4 5%
Other 14 18%
Unknown 14 18%
Readers by discipline Count As %
Medicine and Dentistry 15 19%
Biochemistry, Genetics and Molecular Biology 13 16%
Agricultural and Biological Sciences 9 11%
Nursing and Health Professions 4 5%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Other 16 20%
Unknown 18 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2017.
All research outputs
#1,847,650
of 22,865,319 outputs
Outputs from BMC Cancer
#290
of 8,320 outputs
Outputs of similar age
#32,303
of 299,499 outputs
Outputs of similar age from BMC Cancer
#7
of 132 outputs
Altmetric has tracked 22,865,319 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,320 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,499 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 132 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.