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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Control of adult neurogenesis by programmed cell death in the mammalian brain
|
|---|---|
| Published in |
Molecular Brain, April 2016
|
| DOI | 10.1186/s13041-016-0224-4 |
| Pubmed ID | |
| Authors |
Jae Ryun Ryu, Caroline Jeeyeon Hong, Joo Yeon Kim, Eun-Kyoung Kim, Woong Sun, Seong-Woon Yu |
| Abstract |
The presence of neural stem cells (NSCs) and the production of new neurons in the adult brain have received great attention from scientists and the public because of implications to brain plasticity and their potential use for treating currently incurable brain diseases. Adult neurogenesis is controlled at multiple levels, including proliferation, differentiation, migration, and programmed cell death (PCD). Among these, PCD is the last and most prominent process for regulating the final number of mature neurons integrated into neural circuits. PCD can be classified into apoptosis, necrosis, and autophagic cell death and emerging evidence suggests that all three may be important modes of cell death in neural stem/progenitor cells. However, the molecular mechanisms that regulate PCD and thereby impact the intricate balance between self-renewal, proliferation, and differentiation during adult neurogenesis are not well understood. In this comprehensive review, we focus on the extent, mechanism, and biological significance of PCD for the control of adult neurogenesis in the mammalian brain. The role of intrinsic and extrinsic factors in the regulation of PCD at the molecular and systems levels is also discussed. Adult neurogenesis is a dynamic process, and the signals for differentiation, proliferation, and death of neural progenitor/stem cells are closely interrelated. A better understanding of how adult neurogenesis is influenced by PCD will help lead to important insights relevant to brain health and diseases. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 208 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Morocco | 1 | <1% |
| Unknown | 206 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 44 | 21% |
| Student > Master | 33 | 16% |
| Student > Bachelor | 32 | 15% |
| Researcher | 18 | 9% |
| Student > Postgraduate | 11 | 5% |
| Other | 20 | 10% |
| Unknown | 50 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 44 | 21% |
| Biochemistry, Genetics and Molecular Biology | 42 | 20% |
| Agricultural and Biological Sciences | 34 | 16% |
| Medicine and Dentistry | 20 | 10% |
| Nursing and Health Professions | 2 | <1% |
| Other | 12 | 6% |
| Unknown | 54 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 January 2017.
All research outputs
#1,827,290
of 22,865,319 outputs
Outputs from Molecular Brain
#49
of 1,110 outputs
Outputs of similar age
#31,964
of 299,499 outputs
Outputs of similar age from Molecular Brain
#3
of 35 outputs
Altmetric has tracked 22,865,319 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,110 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,499 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.