Title |
Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral Latent Membrane Protein 1 and the immunomodulatory protein galectin 9
|
---|---|
Published in |
BMC Cancer, December 2006
|
DOI | 10.1186/1471-2407-6-283 |
Pubmed ID | |
Authors |
Cécile Keryer-Bibens, Catherine Pioche-Durieu, Cécile Villemant, Sylvie Souquère, Nozomu Nishi, Mitsuomi Hirashima, Jaap Middeldorp, Pierre Busson |
Abstract |
Nasopharyngeal carcinomas (NPC) are consistently associated with the Epstein-Barr virus (EBV). Their malignant epithelial cells contain the viral genome and express several antigenic viral proteins. However, the mechanisms of immune escape in NPCs are still poorly understood. EBV-transformed B-cells have been reported to release exosomes carrying the EBV-encoded latent membrane protein 1 (LMP1) which has T-cell inhibitory activity. Although this report suggested that NPC cells could also produce exosomes carrying immunosuppressive proteins, this hypothesis has remained so far untested. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
Netherlands | 2 | 1% |
Australia | 1 | <1% |
Japan | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 137 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 32 | 22% |
Researcher | 25 | 17% |
Student > Bachelor | 17 | 12% |
Student > Master | 12 | 8% |
Other | 7 | 5% |
Other | 21 | 14% |
Unknown | 31 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 39 | 27% |
Biochemistry, Genetics and Molecular Biology | 31 | 21% |
Medicine and Dentistry | 23 | 16% |
Immunology and Microbiology | 11 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Other | 6 | 4% |
Unknown | 32 | 22% |