Title |
A comparison between diuretics and angiotensin-receptor blocker agents in patients with stage I hypertension (PREVER-treatment trial): study protocol for a randomized double-blind controlled trial
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Published in |
Trials, February 2011
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DOI | 10.1186/1745-6215-12-53 |
Pubmed ID | |
Authors |
Flávio D Fuchs, Sandra C Fuchs, Leila B Moreira, Miguel Gus, Antônio C Nóbrega, Carlos E Poli-de-Figueiredo, Décio Mion, Luiz Bortolotto, Fernanda Consolim-Colombo, Fernando Nobre, Eduardo Barbosa Coelho, José F Vilela-Martin, Heitor Moreno, Evandro José Cesarino, Roberto Franco, Andréa Araujo Brandão, Marcos R de Sousa, Antônio Luiz Pinho Ribeiro, Paulo Cesar Jardim, Abrahão Afiune Neto, Luiz César N Scala, Marco Mota, Hilton Chaves, João Guilherme Alves, Dario C Sobral Filho, Ricardo Pereira e Silva, José A Figueiredo Neto, Maria Cláudia Irigoyen, Iran Castro, André Avelino Steffens, Rosane Schlatter, Renato Bandeira de Mello, Francisca Mosele, Flávia Ghizzoni, Otávio Berwanger |
Abstract |
Cardiovascular disease is the leading cause of death in Brazil, and hypertension is its major risk factor. The benefit of its drug treatment to prevent major cardiovascular events was consistently demonstrated. Angiotensin-receptor blockers (ARB) have been the preferential drugs in the management of hypertension worldwide, despite the absence of any consistent evidence of advantage over older agents, and the concern that they may be associated with lower renal protection and risk for cancer. Diuretics are as efficacious as other agents, are well tolerated, have longer duration of action and low cost, but have been scarcely compared with ARBs. A study comparing diuretic and ARB is therefore warranted. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 98 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 15% |
Student > Master | 14 | 14% |
Student > Bachelor | 11 | 11% |
Student > Ph. D. Student | 7 | 7% |
Student > Postgraduate | 7 | 7% |
Other | 27 | 27% |
Unknown | 20 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 42 | 42% |
Nursing and Health Professions | 8 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
Agricultural and Biological Sciences | 5 | 5% |
Psychology | 3 | 3% |
Other | 10 | 10% |
Unknown | 27 | 27% |