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A comparison between diuretics and angiotensin-receptor blocker agents in patients with stage I hypertension (PREVER-treatment trial): study protocol for a randomized double-blind controlled trial

Overview of attention for article published in Trials, February 2011
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Title
A comparison between diuretics and angiotensin-receptor blocker agents in patients with stage I hypertension (PREVER-treatment trial): study protocol for a randomized double-blind controlled trial
Published in
Trials, February 2011
DOI 10.1186/1745-6215-12-53
Pubmed ID
Authors

Flávio D Fuchs, Sandra C Fuchs, Leila B Moreira, Miguel Gus, Antônio C Nóbrega, Carlos E Poli-de-Figueiredo, Décio Mion, Luiz Bortolotto, Fernanda Consolim-Colombo, Fernando Nobre, Eduardo Barbosa Coelho, José F Vilela-Martin, Heitor Moreno, Evandro José Cesarino, Roberto Franco, Andréa Araujo Brandão, Marcos R de Sousa, Antônio Luiz Pinho Ribeiro, Paulo Cesar Jardim, Abrahão Afiune Neto, Luiz César N Scala, Marco Mota, Hilton Chaves, João Guilherme Alves, Dario C Sobral Filho, Ricardo Pereira e Silva, José A Figueiredo Neto, Maria Cláudia Irigoyen, Iran Castro, André Avelino Steffens, Rosane Schlatter, Renato Bandeira de Mello, Francisca Mosele, Flávia Ghizzoni, Otávio Berwanger

Abstract

Cardiovascular disease is the leading cause of death in Brazil, and hypertension is its major risk factor. The benefit of its drug treatment to prevent major cardiovascular events was consistently demonstrated. Angiotensin-receptor blockers (ARB) have been the preferential drugs in the management of hypertension worldwide, despite the absence of any consistent evidence of advantage over older agents, and the concern that they may be associated with lower renal protection and risk for cancer. Diuretics are as efficacious as other agents, are well tolerated, have longer duration of action and low cost, but have been scarcely compared with ARBs. A study comparing diuretic and ARB is therefore warranted.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Spain 1 <1%
Brazil 1 <1%
Unknown 98 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 15%
Student > Master 14 14%
Student > Bachelor 11 11%
Student > Ph. D. Student 7 7%
Student > Postgraduate 7 7%
Other 27 27%
Unknown 20 20%
Readers by discipline Count As %
Medicine and Dentistry 42 42%
Nursing and Health Professions 8 8%
Pharmacology, Toxicology and Pharmaceutical Science 6 6%
Agricultural and Biological Sciences 5 5%
Psychology 3 3%
Other 10 10%
Unknown 27 27%