You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy
|
|---|---|
| Published in |
Vascular Cell, April 2012
|
| DOI | 10.1186/2045-824x-4-7 |
| Pubmed ID | |
| Authors |
Jian-Wei Gu, Paola Rizzo, Antonio Pannuti, Todd Golde, Barbara Osborne, Lucio Miele |
| Abstract |
Anti-angiogenesis agents and the identification of cancer stem-like cells (CSC) are opening new avenues for targeted cancer therapy. Recent evidence indicates that angiogenesis regulatory pathways and developmental pathways that control CSC fate are intimately connected, and that endothelial cells are a key component of the CSC niche. Numerous anti-angiogenic therapies developed so far target the VEGF pathway. However, VEGF-targeted therapy is hindered by clinical resistance and side effects, and new approaches are needed. One such approach may be direct targeting of tumor endothelial cell fate determination. Interfering with tumor endothelial cells growth and survival could inhibit not only angiogenesis but also the self-replication of CSC, which relies on signals from surrounding endothelial cells in the tumor microenvironment. The Notch pathway is central to controlling cell fate both during angiogenesis and in CSC from several tumors. A number of investigational Notch inhibitors are being developed. Understanding how Notch interacts with other factors that control endothelial cell functions and angiogenesis in cancers could pave the way to innovative therapeutic strategies that simultaneously target angiogenesis and CSC. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | 1% |
| Switzerland | 1 | 1% |
| Netherlands | 1 | 1% |
| France | 1 | 1% |
| Pakistan | 1 | 1% |
| United Kingdom | 1 | 1% |
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 70 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 26% |
| Student > Master | 15 | 19% |
| Researcher | 11 | 14% |
| Professor | 8 | 10% |
| Student > Bachelor | 5 | 6% |
| Other | 7 | 9% |
| Unknown | 12 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 36% |
| Biochemistry, Genetics and Molecular Biology | 19 | 24% |
| Medicine and Dentistry | 11 | 14% |
| Engineering | 2 | 3% |
| Chemistry | 2 | 3% |
| Other | 2 | 3% |
| Unknown | 14 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2012.
All research outputs
#16,721,208
of 25,371,288 outputs
Outputs from Vascular Cell
#46
of 72 outputs
Outputs of similar age
#109,820
of 173,761 outputs
Outputs of similar age from Vascular Cell
#2
of 4 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 72 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,761 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.