Title |
Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing
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Published in |
Military Medical Research, October 2019
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DOI | 10.1186/s40779-019-0222-9 |
Pubmed ID | |
Authors |
Jing-jing Ji, Jie Fan |
Abstract |
The lung plays a vital role in maintaining homeostasis, as it is responsible for the exchange of oxygen and carbon dioxide. Pulmonary homeostasis is maintained by a network of tissue-resident cells, including epithelial cells, endothelial cells and leukocytes. Myeloid cells of the innate immune system and epithelial cells form a critical barrier in the lung. Recently developed unbiased next generation sequencing (NGS) has revealed cell heterogeneity in the lung with respect to physiology and pathology and has reshaped our knowledge. New phenotypes and distinct gene signatures have been identified, and these new findings enhance the diagnosis and treatment of lung diseases. Here, we present a review of the new NGS findings on myeloid cells in lung development, homeostasis, and lung diseases, including acute lung injury (ALI), lung fibrosis, chronic obstructive pulmonary disease (COPD), and lung cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 16% |
Student > Bachelor | 3 | 10% |
Student > Ph. D. Student | 3 | 10% |
Student > Doctoral Student | 2 | 6% |
Professor | 2 | 6% |
Other | 3 | 10% |
Unknown | 13 | 42% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 6 | 19% |
Medicine and Dentistry | 4 | 13% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Business, Management and Accounting | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 2 | 6% |
Unknown | 16 | 52% |