Title |
Molecular network profiling of U373MG human glioblastoma cells following induction of apoptosis by novel marine-derived anti-cancer 1,2,3,4-tetrahydroisoquinoline alkaloids
|
---|---|
Published in |
Cancer Cell International, April 2012
|
DOI | 10.1186/1475-2867-12-14 |
Pubmed ID | |
Authors |
Hiroko Tabunoki, Naoki Saito, Khanit Suwanborirux, Kornvika Charupant, Jun-ichi Satoh |
Abstract |
Glioblastoma is the most aggressive form of brain tumors showing resistance to treatment with various chemotherapeutic agents. The most effective way to eradicate glioblastoma requires the concurrent inhibition of multiple signaling pathways and target molecules involved in the progression of glioblastoma. Recently, we obtained a series of 1,2,3,4-tetrahydroisoquinoline alkaloids with potent anti-cancer activities, including ecteinascidin-770 (ET-770; the compound 1a) and renieramycin M (RM; the compound 2a) from Thai marine invertebrates, together with a 2'-N-4"-pyridinecarbonyl derivative of ET-770 (the compound 3). We attempted to characterize the molecular pathways responsible for cytotoxic effects of these compounds on a human glioblastoma cell line U373MG. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 3% |
Unknown | 35 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 22% |
Student > Master | 6 | 17% |
Researcher | 5 | 14% |
Student > Bachelor | 4 | 11% |
Student > Doctoral Student | 2 | 6% |
Other | 2 | 6% |
Unknown | 9 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 14% |
Biochemistry, Genetics and Molecular Biology | 5 | 14% |
Chemistry | 5 | 14% |
Medicine and Dentistry | 3 | 8% |
Other | 3 | 8% |
Unknown | 9 | 25% |