Title |
Topiramate-induced severe heatstroke in an adult patient: a case report
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Published in |
Journal of Medical Case Reports, April 2016
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DOI | 10.1186/s13256-016-0835-5 |
Pubmed ID | |
Authors |
Lucie Canel, Sofia Zisimopoulou, Marie Besson, Mathieu Nendaz |
Abstract |
Heatstroke is a life-threatening condition defined by failure of heat load dissipation, resulting in a core temperature higher than 40 °C (104 °F) associated with neurological dysfunction. Topiramate may cause anhidrosis, potentially resulting in heatstroke, as reported especially in children. A 57-year-old Caucasian man was admitted to the emergency room in a febrile comatose state. After a complete workup ruling out the usual etiologies of such a condition, we assumed the hypothesis of a heatstroke caused by topiramate, recently prescribed for essential tremor. Topiramate-related heatstroke has been described in children but must be recognized in adults as well. Outcomes may range from total clinical recovery to persistent neurological dysfunction or death. The prescription of topiramate and the follow-up of adult patients under this medication should include an evaluation of hypohidrosis, especially in contexts of high temperature. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Saudi Arabia | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 18% |
Other | 4 | 14% |
Student > Master | 4 | 14% |
Student > Ph. D. Student | 4 | 14% |
Student > Bachelor | 2 | 7% |
Other | 5 | 18% |
Unknown | 4 | 14% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 36% |
Computer Science | 3 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Engineering | 2 | 7% |
Social Sciences | 2 | 7% |
Other | 3 | 11% |
Unknown | 6 | 21% |