Title |
General lack of global dosage compensation in ZZ/ZW systems? Broadening the perspective with RNA-seq
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Published in |
BMC Genomics, February 2011
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DOI | 10.1186/1471-2164-12-91 |
Pubmed ID | |
Authors |
Jochen BW Wolf, Jarosław Bryk |
Abstract |
Species with heteromorphic sex chromosomes face the challenge of large-scale imbalance in gene dose. Microarray-based studies in several independent male heterogametic XX/XY systems suggest that dosage compensation mechanisms are in place to mitigate the detrimental effects of gene dose differences. However, recent genomic research on female heterogametic ZZ/ZW systems has generated surprising results. In two bird species and one lepidopteran no evidence for a global dosage compensating mechanism has been found. The recent advent of massively parallel RNA sequencing now opens up the possibility to gauge the generality of this observation with a broader phylogenetic sampling. It further allows assessing the validity of microarray-based inference on dosage compensation with a novel technology. |
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Other | 12 | 11% |
Unknown | 7 | 6% |
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