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Effectiveness of the Polish program for the treatment of severe allergic asthma with omalizumab: a single-center experience

Overview of attention for article published in BMC Pulmonary Medicine, April 2016
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Title
Effectiveness of the Polish program for the treatment of severe allergic asthma with omalizumab: a single-center experience
Published in
BMC Pulmonary Medicine, April 2016
DOI 10.1186/s12890-016-0224-2
Pubmed ID
Authors

Izabela Kupryś-Lipińska, Paweł Majak, Joanna Molinska, Piotr Kuna

Abstract

A national program for the treatment of severe allergic (IgE-dependent) asthma with omalizumab (OMA) was implemented in Poland in 2013. This observational study evaluated the effectiveness of the Polish OMA program and monitored asthma control after treatment discontinuation. In the first year of the program, 53 patients (23 new/30 continuing treatment) received OMA in the Barlicki Hospital, Poland. Patients were evaluated at baseline and after 16 weeks of OMA treatment by spirometry, mean dose of inhaled corticosteroids (ICS) and oral corticosteroids (OCS), number of asthma exacerbations, the Asthma Control Questionnaire (ACQ), and the Asthma Quality of Life Questionnaire (AQLQ). OMA treatment responses were determined using the global effectiveness of treatment evaluation scale. Fourteen patients ceased OMA treatment following ≥36 months of therapy and entered follow up. All patients treated with OMA de novo for at least 16 weeks had a decrease in asthma exacerbations and showed a good (15/16, 94 %) or an excellent (1/16, 6 %) response to treatment. We observed a reduction in OCS dose (≥5 mg/day) in 14/16 (88 %) patients. ACQ and AQLQ scores improved by ≥0.5 points in 15/16 (94 %) and 14/16 (88 %) patients, respectively. After OMA cessation, 11/14 (79 %) patients showed worsening of asthma control and severe exacerbations. Patients in the OMA program show significant benefits, including reduced use of OCS, improved asthma control and quality of life. After OMA discontinuation, frequent severe exacerbations were observed primarily in patients whose asthma was previously uncontrolled by high OCS doses.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 13%
Researcher 4 10%
Student > Doctoral Student 4 10%
Other 4 10%
Student > Ph. D. Student 4 10%
Other 9 23%
Unknown 9 23%
Readers by discipline Count As %
Medicine and Dentistry 15 38%
Biochemistry, Genetics and Molecular Biology 4 10%
Nursing and Health Professions 4 10%
Unspecified 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 4 10%
Unknown 7 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2016.
All research outputs
#18,453,763
of 22,865,319 outputs
Outputs from BMC Pulmonary Medicine
#1,383
of 1,921 outputs
Outputs of similar age
#218,838
of 298,924 outputs
Outputs of similar age from BMC Pulmonary Medicine
#31
of 41 outputs
Altmetric has tracked 22,865,319 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,921 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.