You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
High glucose concentrations induce TNF-α production through the down-regulation of CD33 in primary human monocytes
|
|---|---|
| Published in |
BMC Immunology, April 2012
|
| DOI | 10.1186/1471-2172-13-19 |
| Pubmed ID | |
| Authors |
Yolanda Gonzalez, M Teresa Herrera, Gloria Soldevila, Lourdes Garcia-Garcia, Guadalupe Fabián, E Martha Pérez-Armendariz, Karen Bobadilla, Silvia Guzmán-Beltrán, Eduardo Sada, Martha Torres |
| Abstract |
CD33 is a membrane receptor containing a lectin domain and a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) that is able to inhibit cytokine production. CD33 is expressed by monocytes, and reduced expression of CD33 correlates with augmented production of inflammatory cytokines, such as IL-1β, TNF-α, and IL-8. However, the role of CD33 in the inflammation associated with hyperglycemia and diabetes is unknown. Therefore, we studied CD33 expression and inflammatory cytokine secretion in freshly isolated monocytes from patients with type 2 diabetes. To evaluate the effects of hyperglycemia, monocytes from healthy donors were cultured with different glucose concentrations (15-50 mmol/l D-glucose), and CD33 expression and inflammatory cytokine production were assessed. The expression of suppressor of cytokine signaling protein-3 (SOCS-3) and the generation of reactive oxygen species (ROS) were also evaluated to address the cellular mechanisms involved in the down-regulation of CD33. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| India | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 163 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 19% |
| Student > Master | 26 | 16% |
| Student > Bachelor | 20 | 12% |
| Researcher | 13 | 8% |
| Student > Doctoral Student | 8 | 5% |
| Other | 25 | 15% |
| Unknown | 42 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 22% |
| Medicine and Dentistry | 28 | 17% |
| Biochemistry, Genetics and Molecular Biology | 20 | 12% |
| Immunology and Microbiology | 12 | 7% |
| Neuroscience | 6 | 4% |
| Other | 18 | 11% |
| Unknown | 45 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2022.
All research outputs
#2,060,792
of 23,555,482 outputs
Outputs from BMC Immunology
#18
of 592 outputs
Outputs of similar age
#12,609
of 162,594 outputs
Outputs of similar age from BMC Immunology
#1
of 11 outputs
Altmetric has tracked 23,555,482 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 592 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 162,594 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.