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Traumatic brain injury: pathophysiology for neurocritical care

Overview of attention for article published in Journal of Intensive Care, April 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

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1 blog
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12 X users
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1 Facebook page

Citations

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183 Dimensions

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495 Mendeley
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Title
Traumatic brain injury: pathophysiology for neurocritical care
Published in
Journal of Intensive Care, April 2016
DOI 10.1186/s40560-016-0138-3
Pubmed ID
Authors

Kosaku Kinoshita

Abstract

Severe cases of traumatic brain injury (TBI) require neurocritical care, the goal being to stabilize hemodynamics and systemic oxygenation to prevent secondary brain injury. It is reported that approximately 45 % of dysoxygenation episodes during critical care have both extracranial and intracranial causes, such as intracranial hypertension and brain edema. For this reason, neurocritical care is incomplete if it only focuses on prevention of increased intracranial pressure (ICP) or decreased cerebral perfusion pressure (CPP). Arterial hypotension is a major risk factor for secondary brain injury, but hypertension with a loss of autoregulation response or excess hyperventilation to reduce ICP can also result in a critical condition in the brain and is associated with a poor outcome after TBI. Moreover, brain injury itself stimulates systemic inflammation, leading to increased permeability of the blood-brain barrier, exacerbated by secondary brain injury and resulting in increased ICP. Indeed, systemic inflammatory response syndrome after TBI reflects the extent of tissue damage at onset and predicts further tissue disruption, producing a worsening clinical condition and ultimately a poor outcome. Elevation of blood catecholamine levels after severe brain damage has been reported to contribute to the regulation of the cytokine network, but this phenomenon is a systemic protective response against systemic insults. Catecholamines are directly involved in the regulation of cytokines, and elevated levels appear to influence the immune system during stress. Medical complications are the leading cause of late morbidity and mortality in many types of brain damage. Neurocritical care after severe TBI has therefore been refined to focus not only on secondary brain injury but also on systemic organ damage after excitation of sympathetic nerves following a stress reaction.

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X Demographics

The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 495 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 <1%
Mexico 1 <1%
Unknown 493 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 78 16%
Student > Master 58 12%
Student > Postgraduate 48 10%
Other 37 7%
Student > Ph. D. Student 37 7%
Other 88 18%
Unknown 149 30%
Readers by discipline Count As %
Medicine and Dentistry 173 35%
Nursing and Health Professions 49 10%
Neuroscience 37 7%
Biochemistry, Genetics and Molecular Biology 13 3%
Pharmacology, Toxicology and Pharmaceutical Science 9 2%
Other 45 9%
Unknown 169 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2021.
All research outputs
#2,109,923
of 22,749,166 outputs
Outputs from Journal of Intensive Care
#98
of 511 outputs
Outputs of similar age
#36,338
of 298,868 outputs
Outputs of similar age from Journal of Intensive Care
#6
of 21 outputs
Altmetric has tracked 22,749,166 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 511 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,868 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.