Title |
Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling
|
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Published in |
Journal of Neuroinflammation, April 2012
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DOI | 10.1186/1742-2094-9-67 |
Pubmed ID | |
Authors |
Elaine L Pranski, Nirjari V Dalal, Jeremy H Herskowitz, Adam L Orr, Leah A Roesch, Jason J Fritz, Craig Heilman, James J Lah, Allan I Levey, Ranjita S Betarbet |
Abstract |
The RING domain-containing protein RING finger protein 11 (RNF11) is a member of the A20 ubiquitin-editing protein complex and modulates peripheral NF-κB signaling. RNF11 is robustly expressed in neurons and colocalizes with a population of α-synuclein-positive Lewy bodies and neurites in Parkinson disease patients. The NF-κB pathway has an important role in the vertebrate nervous system, where the absence of NF-κB activity during development can result in learning and memory deficits, whereas chronic NF-κB activation is associated with persistent neuroinflammation. We examined the functional role of RNF11 with respect to canonical NF-κB signaling in neurons to gain understanding of the tight association of inflammatory pathways, including NF-κB, with the pathogenesis of neurodegenerative diseases. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 28% |
Student > Master | 4 | 14% |
Professor | 3 | 10% |
Researcher | 3 | 10% |
Student > Postgraduate | 3 | 10% |
Other | 6 | 21% |
Unknown | 2 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 34% |
Biochemistry, Genetics and Molecular Biology | 4 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Immunology and Microbiology | 2 | 7% |
Medicine and Dentistry | 2 | 7% |
Other | 6 | 21% |
Unknown | 3 | 10% |