Title |
Adenosine 5′-triphosphate (ATP) supplements are not orally bioavailable: a randomized, placebo-controlled cross-over trial in healthy humans
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Published in |
Journal of the International Society of Sports Nutrition, April 2022
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DOI | 10.1186/1550-2783-9-16 |
Pubmed ID | |
Authors |
Ilja CW Arts, Erik JCM Coolen, Martijn JL Bours, Nathalie Huyghebaert, Martien A Cohen Stuart, Aalt Bast, Pieter C Dagnelie |
Abstract |
Nutritional supplements designed to increase adenosine 5'-triphosphate (ATP) concentrations are commonly used by athletes as ergogenic aids. ATP is the primary source of energy for the cells, and supplementation may enhance the ability to maintain high ATP turnover during high-intensity exercise. Oral ATP supplements have beneficial effects in some but not all studies examining physical performance. One of the remaining questions is whether orally administered ATP is bioavailable. We investigated whether acute supplementation with oral ATP administered as enteric-coated pellets led to increased concentrations of ATP or its metabolites in the circulation. |
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Mendeley readers
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