Title |
The effect of bone marrow microenvironment on the functional properties of the therapeutic bone marrow-derived cells in patients with acute myocardial infarction
|
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Published in |
Journal of Translational Medicine, April 2012
|
DOI | 10.1186/1479-5876-10-66 |
Pubmed ID | |
Authors |
Johanna A Miettinen, Riikka J Salonen, Kari Ylitalo, Matti Niemelä, Kari Kervinen, Marjaana Säily, Pirjo Koistinen, Eeva-Riitta Savolainen, Timo H Mäkikallio, Heikki V Huikuri, Petri Lehenkari |
Abstract |
Treatment of acute myocardial infarction with stem cell transplantation has achieved beneficial effects in many clinical trials. The bone marrow microenvironment of ST-elevation myocardial infarction (STEMI) patients has never been studied even though myocardial infarction is known to cause an imbalance in the acid-base status of these patients. The aim of this study was to assess if the blood gas levels in the bone marrow of STEMI patients affect the characteristics of the bone marrow cells (BMCs) and, furthermore, do they influence the change in cardiac function after autologous BMC transplantation. The arterial, venous and bone marrow blood gas concentrations were also compared. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 1% |
Poland | 1 | 1% |
Unknown | 75 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 16% |
Researcher | 10 | 13% |
Student > Postgraduate | 9 | 12% |
Student > Master | 8 | 10% |
Other | 6 | 8% |
Other | 14 | 18% |
Unknown | 18 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 26% |
Agricultural and Biological Sciences | 10 | 13% |
Biochemistry, Genetics and Molecular Biology | 9 | 12% |
Engineering | 5 | 6% |
Business, Management and Accounting | 3 | 4% |
Other | 9 | 12% |
Unknown | 21 | 27% |