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Clobetasol promotes remyelination in a mouse model of neuromyelitis optica

Overview of attention for article published in Acta Neuropathologica Communications, April 2016
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Title
Clobetasol promotes remyelination in a mouse model of neuromyelitis optica
Published in
Acta Neuropathologica Communications, April 2016
DOI 10.1186/s40478-016-0309-4
Pubmed ID
Authors

Xiaoming Yao, Tao Su, A. S. Verkman

Abstract

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system that can produce marked neurological deficit. Current NMO therapies include immunosuppressants, plasma exchange and B-cell depletion. Here, we evaluated 14 potential remyelinating drugs emerging from prior small molecule screens done to identify drugs for repurposing in multiple sclerosis and other demyelinating neurological diseases. Compounds were initially evaluated in oligodendrocyte precursor cell (OPC) and cerebellar slice cultures, and then in a mouse model of NMO produced by intracerebral injection of anti-AQP4 autoantibody (AQP4-IgG) and human complement characterized by demyelination with minimal axonal damage. The FDA-approved drug clobetasol promoted differentiation in OPC cultures and remyelination in cerebellar slice cultures and in mice. Intraperitoneal administration of 2 mg/kg/day clobetasol reduced myelin loss by ~60 %, even when clobetasol was administered after demyelination occurred. Clobetasol increased the number of mature oligodendrocytes within lesions without significantly altering initial astrocyte damage or inflammation. These results provide proof-of-concept for the potential utility of a remyelinating approach in the treatment of NMO.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 26%
Student > Ph. D. Student 9 21%
Student > Bachelor 7 17%
Student > Master 4 10%
Student > Doctoral Student 2 5%
Other 3 7%
Unknown 6 14%
Readers by discipline Count As %
Neuroscience 11 26%
Biochemistry, Genetics and Molecular Biology 8 19%
Agricultural and Biological Sciences 6 14%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Medicine and Dentistry 2 5%
Other 5 12%
Unknown 8 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2016.
All research outputs
#6,597,475
of 7,621,460 outputs
Outputs from Acta Neuropathologica Communications
#332
of 356 outputs
Outputs of similar age
#223,535
of 266,738 outputs
Outputs of similar age from Acta Neuropathologica Communications
#29
of 31 outputs
Altmetric has tracked 7,621,460 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 356 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,738 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.