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Epigenetic assimilation in the aging human brain

Overview of attention for article published in Genome Biology (Online Edition), April 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)

Mentioned by

news
6 news outlets
blogs
1 blog
twitter
16 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
38 Dimensions

Readers on

mendeley
109 Mendeley
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Title
Epigenetic assimilation in the aging human brain
Published in
Genome Biology (Online Edition), April 2016
DOI 10.1186/s13059-016-0946-8
Pubmed ID
Authors

Gabriel Oh, Sasha Ebrahimi, Sun-Chong Wang, Rene Cortese, Zachary A. Kaminsky, Irving I. Gottesman, James R. Burke, Brenda L. Plassman, Art Petronis

Abstract

Epigenetic drift progressively increases variation in DNA modification profiles of aging cells, but the finale of such divergence remains elusive. In this study, we explored the dynamics of DNA modification and transcription in the later stages of human life. We find that brain tissues of older individuals (>75 years) become more similar to each other, both epigenetically and transcriptionally, compared with younger individuals. Inter-individual epigenetic assimilation is concurrent with increasing similarity between the cerebral cortex and the cerebellum, which points to potential brain cell dedifferentiation. DNA modification analysis of twins affected with Alzheimer's disease reveals a potential for accelerated epigenetic assimilation in neurodegenerative disease. We also observe loss of boundaries and merging of neighboring DNA modification and transcriptomic domains over time. Age-dependent epigenetic divergence, paradoxically, changes to convergence in the later stages of life. The newly described phenomena of epigenetic assimilation and tissue dedifferentiation may help us better understand the molecular mechanisms of aging and the origins of diseases for which age is a risk factor.

Twitter Demographics

The data shown below were collected from the profiles of 16 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Germany 1 <1%
Canada 1 <1%
Unknown 105 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 19%
Researcher 19 17%
Student > Bachelor 16 15%
Student > Doctoral Student 9 8%
Professor 7 6%
Other 21 19%
Unknown 16 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 30 28%
Agricultural and Biological Sciences 21 19%
Neuroscience 15 14%
Medicine and Dentistry 8 7%
Psychology 6 6%
Other 9 8%
Unknown 20 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 62. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2016.
All research outputs
#471,599
of 19,534,140 outputs
Outputs from Genome Biology (Online Edition)
#379
of 3,847 outputs
Outputs of similar age
#10,688
of 274,913 outputs
Outputs of similar age from Genome Biology (Online Edition)
#1
of 1 outputs
Altmetric has tracked 19,534,140 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,847 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,913 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them