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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Epigenetic assimilation in the aging human brain
|
|---|---|
| Published in |
Genome Biology, April 2016
|
| DOI | 10.1186/s13059-016-0946-8 |
| Pubmed ID | |
| Authors |
Gabriel Oh, Sasha Ebrahimi, Sun-Chong Wang, Rene Cortese, Zachary A. Kaminsky, Irving I. Gottesman, James R. Burke, Brenda L. Plassman, Art Petronis |
| Abstract |
Epigenetic drift progressively increases variation in DNA modification profiles of aging cells, but the finale of such divergence remains elusive. In this study, we explored the dynamics of DNA modification and transcription in the later stages of human life. We find that brain tissues of older individuals (>75 years) become more similar to each other, both epigenetically and transcriptionally, compared with younger individuals. Inter-individual epigenetic assimilation is concurrent with increasing similarity between the cerebral cortex and the cerebellum, which points to potential brain cell dedifferentiation. DNA modification analysis of twins affected with Alzheimer's disease reveals a potential for accelerated epigenetic assimilation in neurodegenerative disease. We also observe loss of boundaries and merging of neighboring DNA modification and transcriptomic domains over time. Age-dependent epigenetic divergence, paradoxically, changes to convergence in the later stages of life. The newly described phenomena of epigenetic assimilation and tissue dedifferentiation may help us better understand the molecular mechanisms of aging and the origins of diseases for which age is a risk factor. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 19% |
| United States | 3 | 19% |
| Canada | 1 | 6% |
| France | 1 | 6% |
| Germany | 1 | 6% |
| Australia | 1 | 6% |
| Japan | 1 | 6% |
| Unknown | 5 | 31% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 69% |
| Scientists | 4 | 25% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 108 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 19% |
| Researcher | 19 | 17% |
| Student > Bachelor | 17 | 15% |
| Student > Doctoral Student | 9 | 8% |
| Professor | 7 | 6% |
| Other | 21 | 19% |
| Unknown | 18 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 27% |
| Agricultural and Biological Sciences | 21 | 19% |
| Neuroscience | 16 | 14% |
| Medicine and Dentistry | 8 | 7% |
| Psychology | 6 | 5% |
| Other | 9 | 8% |
| Unknown | 22 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 62. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2016.
All research outputs
#630,380
of 24,003,070 outputs
Outputs from Genome Biology
#433
of 4,279 outputs
Outputs of similar age
#11,969
of 302,584 outputs
Outputs of similar age from Genome Biology
#7
of 80 outputs
Altmetric has tracked 24,003,070 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,279 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.9. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 302,584 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.