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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Attenuation of neuroinflammation reverses Adriamycin-induced cognitive impairments
|
|---|---|
| Published in |
Acta Neuropathologica Communications, November 2019
|
| DOI | 10.1186/s40478-019-0838-8 |
| Pubmed ID | |
| Authors |
Barrett D. Allen, Lauren A. Apodaca, Amber R. Syage, Mineh Markarian, Al Anoud D. Baddour, Harutyun Minasyan, Leila Alikhani, Celine Lu, Brian L. West, Erich Giedzinski, Janet E. Baulch, Munjal M. Acharya |
| Abstract |
Numerous clinical studies have established the debilitating neurocognitive side effects of chemotherapy in the treatment of breast cancer, often referred as chemobrain. We hypothesize that cognitive impairments are associated with elevated microglial inflammation in the brain. Thus, either elimination of microglia or restoration of microglial function could ameliorate cognitive dysfunction. Using a rodent model of chronic Adriamycin (ADR) treatment, a commonly used breast cancer chemotherapy, we evaluated two strategies to ameliorate chemobrain: 1) microglia depletion using the colony stimulating factor-1 receptor (CSF1R) inhibitor PLX5622 and 2) human induced pluripotent stem cell-derived microglia (iMG)-derived extracellular vesicle (EV) treatment. In strategy 1 mice received ADR once weekly for 4 weeks and were then administered CSF1R inhibitor (PLX5622) starting 72 h post-ADR treatment. ADR-treated animals given a normal diet exhibited significant behavioral deficits and increased microglial activation 4-6 weeks later. PLX5622-treated mice exhibited no ADR-related cognitive deficits and near complete depletion of IBA-1 and CD68+ microglia in the brain. Cytokine and RNA sequencing analysis for inflammation pathways validated these findings. In strategy 2, 1 week after the last ADR treatment, mice received retro-orbital vein injections of iMG-EV (once weekly for 4 weeks) and 1 week later, mice underwent behavior testing. ADR-treated mice receiving EV showed nearly complete restoration of cognitive function and significant reductions in microglial activation as compared to untreated ADR mice. Our data demonstrate that ADR treatment elevates CNS inflammation that is linked to cognitive dysfunction and that attenuation of neuroinflammation reverses the adverse neurocognitive effects of chemotherapy. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 55 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 20% |
| Researcher | 5 | 9% |
| Student > Bachelor | 3 | 5% |
| Other | 3 | 5% |
| Student > Postgraduate | 3 | 5% |
| Other | 8 | 15% |
| Unknown | 22 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 7 | 13% |
| Biochemistry, Genetics and Molecular Biology | 5 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
| Psychology | 4 | 7% |
| Agricultural and Biological Sciences | 3 | 5% |
| Other | 8 | 15% |
| Unknown | 24 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2019.
All research outputs
#15,664,059
of 25,271,884 outputs
Outputs from Acta Neuropathologica Communications
#1,196
of 1,567 outputs
Outputs of similar age
#254,250
of 471,899 outputs
Outputs of similar age from Acta Neuropathologica Communications
#63
of 69 outputs
Altmetric has tracked 25,271,884 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,567 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.7. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 471,899 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.