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Oxygen radical-mediated oxidation reactions of an alanine peptide motif - density functional theory and transition state theory study

Overview of attention for article published in BMC Chemistry, April 2012
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Title
Oxygen radical-mediated oxidation reactions of an alanine peptide motif - density functional theory and transition state theory study
Published in
BMC Chemistry, April 2012
DOI 10.1186/1752-153x-6-33
Pubmed ID
Authors

Hsing-Yu Chen, Soonmin Jang, Tzyy-Rong Jinn, Jia-Yaw Chang, Hsiu-Feng Lu, Feng-Yin Li

Abstract

Oxygen-base (O-base) oxidation in protein backbone is important in the protein backbone fragmentation due to the attack from reactive oxygen species (ROS). In this study, an alanine peptide was used model system to investigate this O-base oxidation by employing density functional theory (DFT) calculations combining with continuum solvent model. Detailed reaction steps were analyzed along with their reaction rate constants.

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Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 53%
Researcher 4 24%
Student > Bachelor 1 6%
Student > Doctoral Student 1 6%
Unknown 2 12%
Readers by discipline Count As %
Chemistry 9 53%
Physics and Astronomy 2 12%
Agricultural and Biological Sciences 1 6%
Materials Science 1 6%
Engineering 1 6%
Other 0 0%
Unknown 3 18%