Title |
Comparing the mitochondrial genomes of Wolbachia-dependent and independent filarial nematode species
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Published in |
BMC Genomics, April 2012
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DOI | 10.1186/1471-2164-13-145 |
Pubmed ID | |
Authors |
Samantha N McNulty, Andrew S Mullin, Jefferson A Vaughan, Vasyl V Tkach, Gary J Weil, Peter U Fischer |
Abstract |
Many species of filarial nematodes depend on Wolbachia endobacteria to carry out their life cycle. Other species are naturally Wolbachia-free. The biological mechanisms underpinning Wolbachia-dependence and independence in filarial nematodes are not known. Previous studies have indicated that Wolbachia have an impact on mitochondrial gene expression, which may suggest a role in energy metabolism. If Wolbachia can supplement host energy metabolism, reduced mitochondrial function in infected filarial species may account for Wolbachia-dependence. Wolbachia also have a strong influence on mitochondrial evolution due to vertical co-transmission. This could drive alterations in mitochondrial genome sequence in infected species. Comparisons between the mitochondrial genome sequences of Wolbachia-dependent and independent filarial worms may reveal differences indicative of altered mitochondrial function. |
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