Title |
Mitogen Activated Protein Kinase Phosphatase-1 Prevents the Development of Tactile Sensitivity in a Rodent Model of Neuropathic Pain
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Published in |
Molecular Pain, January 2012
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DOI | 10.1186/1744-8069-8-34 |
Pubmed ID | |
Authors |
Christian Ndong, Russell P Landry, Joyce A DeLeo, Edgar Alfonso Romero-Sandoval |
Abstract |
Neuropathic pain due to nerve injury is one of the most difficult types of pain to treat. Following peripheral nerve injury, neuronal and glial plastic changes contribute to central sensitization and perpetuation of mechanical hypersensitivity in rodents. The mitogen activated protein kinase (MAPK) family is pivotal in this spinal cord plasticity. MAPK phosphatases (MKPs) limit inflammatory processes by dephosphorylating MAPKs. For example, MKP-1 preferentially dephosphorylates p-p38. Since spinal p-p38 is pivotal for the development of chronic hypersensitivity in rodent models of pain, and p-p38 inhibitors have shown clinical potential in acute and chronic pain patients, we hypothesize that induction of spinal MKP-1 will prevent the development of peripheral nerve-injury-induced hypersensitivity and p-p38 overexpression. |
X Demographics
Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 3% |
Unknown | 39 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 25% |
Researcher | 6 | 15% |
Student > Master | 5 | 13% |
Student > Bachelor | 3 | 8% |
Professor | 2 | 5% |
Other | 8 | 20% |
Unknown | 6 | 15% |
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Medicine and Dentistry | 6 | 15% |
Biochemistry, Genetics and Molecular Biology | 3 | 8% |
Nursing and Health Professions | 2 | 5% |
Other | 8 | 20% |
Unknown | 7 | 18% |