Title |
Innate immune properties of selected human neuropeptides against Moraxella catarrhalis and nontypeable Haemophilus influenzae
|
---|---|
Published in |
BMC Immunology, May 2012
|
DOI | 10.1186/1471-2172-13-24 |
Pubmed ID | |
Authors |
Daria Augustyniak, Adam Jankowski, Paweł Mackiewicz, Agnieszka Skowyra, Jan Gutowicz, Zuzanna Drulis-Kawa |
Abstract |
Considerable evidence supports the concept of active communication between the nervous and immune systems. One class of such communicators are the neuropeptides (NPs). Recent reports have highlighted the antimicrobial activity of neuropeptides, placing them among the integral components of innate immune defense. This study examined the action of four human neuropeptides: calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), substance P (SP) and somatostatin (SOM), which are accessible in the upper respiratory tract, against two human-specific respiratory pathogens. We studied: (i) neuropeptide-mediated direct antibacterial activity exerted against Moraxella catarrhalis and nontypeable Haemophilus influenzae, and (ii) indirect immunomodulatory role of these neuropeptides in the neutrophil-mediated phagocytosis of indicated pathogens. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 67% |
Argentina | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Poland | 1 | 5% |
Unknown | 21 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 27% |
Other | 2 | 9% |
Student > Bachelor | 2 | 9% |
Student > Postgraduate | 2 | 9% |
Professor > Associate Professor | 2 | 9% |
Other | 5 | 23% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 23% |
Biochemistry, Genetics and Molecular Biology | 4 | 18% |
Immunology and Microbiology | 4 | 18% |
Medicine and Dentistry | 3 | 14% |
Mathematics | 1 | 5% |
Other | 3 | 14% |
Unknown | 2 | 9% |