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Mendeley readers
| Title |
Bisphosphonate-associated osteonecrosis of the jaw is linked to suppressed TGFβ1-signaling and increased Galectin-3 expression: A histological study on biopsies
|
|---|---|
| Published in |
Journal of Translational Medicine, July 2011
|
| DOI | 10.1186/1479-5876-9-102 |
| Pubmed ID | |
| Authors |
Falk Wehrhan, Peter Hyckel, Arndt Guentsch, Emeka Nkenke, Phillip Stockmann, Karl A Schlegel, Friedrich W Neukam, Kerstin Amann |
| Abstract |
Bisphosphonate associated osteonecrosis of the jaw (BRONJ) implies an impairment in oral hard- and soft tissue repair. An understanding of the signal transduction alterations involved can inform therapeutic strategies. Transforming growth factor β1 (TGFβ1) is a critical regulator of tissue repair; galectin-3 mediates tissue differentiation and specifically modulates periodontopathic bacterial infection. The aim of this study was to compare the expression of TGFβ1-related signaling molecules and Galectin-3 in BRONJ-affected and healthy mucosal tissues. To discriminate between BRONJ-specific impairments in TGFβ1 signaling and secondary inflammatory changes, the results were compared to the expression of TGFβ1 and Galectin-3 in mucosal tissues with osteoradionecrosis. |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 1 | 2% |
| France | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 51 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 24% |
| Student > Ph. D. Student | 8 | 15% |
| Student > Master | 6 | 11% |
| Student > Postgraduate | 5 | 9% |
| Professor > Associate Professor | 4 | 7% |
| Other | 10 | 19% |
| Unknown | 8 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 56% |
| Agricultural and Biological Sciences | 5 | 9% |
| Immunology and Microbiology | 3 | 6% |
| Chemistry | 2 | 4% |
| Nursing and Health Professions | 1 | 2% |
| Other | 6 | 11% |
| Unknown | 7 | 13% |