Title |
The prognostic value of expression of HIF1α, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy
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Published in |
Radiation Oncology, April 2012
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DOI | 10.1186/1748-717x-7-66 |
Pubmed ID | |
Authors |
Damien C Weber, Jean-Christophe Tille, Christophe Combescure, Jean-François Egger, Mahomet Laouiti, Karim Hammad, Perrine Granger, Laura Rubbia-Brandt, Raymond Miralbell |
Abstract |
Androgens stimulate the production of hypoxia-inducible factor (HIF1α) and ultimately vascular endothelial growth factor (VEGF-A). Additionally, epithelial growth factor (EGF) mediates HIF1α production. Carbonic anhydrase IX (CAIX) expression is associated with tumor cell hypoxia in a variety of malignancies. This study assesses the prognostic relation between HIF1α, VEGF-A, EGF Receptor and CAIX expression by immunochemistry in diagnostic samples of patients with intermediate- and high-risk localized prostate cancer treated with radiation therapy, with or without androgen deprivation therapy (ADT). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 6 | 17% |
Student > Ph. D. Student | 4 | 11% |
Student > Bachelor | 3 | 9% |
Researcher | 3 | 9% |
Student > Doctoral Student | 2 | 6% |
Other | 7 | 20% |
Unknown | 10 | 29% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 13 | 37% |
Agricultural and Biological Sciences | 3 | 9% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Computer Science | 1 | 3% |
Other | 3 | 9% |
Unknown | 12 | 34% |