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Porcine reproductive and respiratory syndrome virus nonstructural protein 2 contributes to NF-κB activation

Overview of attention for article published in Virology Journal, April 2012
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Title
Porcine reproductive and respiratory syndrome virus nonstructural protein 2 contributes to NF-κB activation
Published in
Virology Journal, April 2012
DOI 10.1186/1743-422x-9-83
Pubmed ID
Authors

Ying Fang, Liurong Fang, Yang Wang, Yingying Lei, Rui Luo, Dang Wang, Huanchun Chen, Shaobo Xiao

Abstract

Nuclear factor-kappaB (NF-κB) is an inducible transcription factor that plays a key role in inflammation and immune responses, as well as in the regulation of cell proliferation and survival. Previous studies by our group and others have demonstrated that porcine reproductive and respiratory syndrome virus (PRRSV) infection could activate NF-κB in MARC-145 cells and alveolar macrophages. The nucleocapsid (N) protein was identified as an NF-κB activator among the structural proteins encoded by PRRSV; however, it remains unclear whether the nonstructural proteins (Nsps) contribute to NF-κB activation. In this study, we identified which Nsps can activate NF-κB and investigated the potential mechanism(s) by which they act.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 5%
Denmark 1 5%
Unknown 18 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 30%
Researcher 4 20%
Other 3 15%
Student > Bachelor 1 5%
Student > Master 1 5%
Other 1 5%
Unknown 4 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 45%
Veterinary Science and Veterinary Medicine 3 15%
Immunology and Microbiology 1 5%
Medicine and Dentistry 1 5%
Unknown 6 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2012.
All research outputs
#18,305,773
of 22,664,644 outputs
Outputs from Virology Journal
#2,420
of 3,029 outputs
Outputs of similar age
#125,548
of 162,569 outputs
Outputs of similar age from Virology Journal
#24
of 42 outputs
Altmetric has tracked 22,664,644 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,029 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.5. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 162,569 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.