Title |
Porcine reproductive and respiratory syndrome virus nonstructural protein 2 contributes to NF-κB activation
|
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Published in |
Virology Journal, April 2012
|
DOI | 10.1186/1743-422x-9-83 |
Pubmed ID | |
Authors |
Ying Fang, Liurong Fang, Yang Wang, Yingying Lei, Rui Luo, Dang Wang, Huanchun Chen, Shaobo Xiao |
Abstract |
Nuclear factor-kappaB (NF-κB) is an inducible transcription factor that plays a key role in inflammation and immune responses, as well as in the regulation of cell proliferation and survival. Previous studies by our group and others have demonstrated that porcine reproductive and respiratory syndrome virus (PRRSV) infection could activate NF-κB in MARC-145 cells and alveolar macrophages. The nucleocapsid (N) protein was identified as an NF-κB activator among the structural proteins encoded by PRRSV; however, it remains unclear whether the nonstructural proteins (Nsps) contribute to NF-κB activation. In this study, we identified which Nsps can activate NF-κB and investigated the potential mechanism(s) by which they act. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 5% |
Denmark | 1 | 5% |
Unknown | 18 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 30% |
Researcher | 4 | 20% |
Other | 3 | 15% |
Student > Bachelor | 1 | 5% |
Student > Master | 1 | 5% |
Other | 1 | 5% |
Unknown | 4 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 45% |
Veterinary Science and Veterinary Medicine | 3 | 15% |
Immunology and Microbiology | 1 | 5% |
Medicine and Dentistry | 1 | 5% |
Unknown | 6 | 30% |