Title |
Trehalose treatment suppresses inflammation, oxidative stress, and vasospasm induced by experimental subarachnoid hemorrhage
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Published in |
Journal of Translational Medicine, April 2012
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DOI | 10.1186/1479-5876-10-80 |
Pubmed ID | |
Authors |
Ryosuke Echigo, Nobuyuki Shimohata, Kensuke Karatsu, Fumiko Yano, Yuko Kayasuga-Kariya, Ayano Fujisawa, Takayo Ohto, Yoshihiro Kita, Motonao Nakamura, Shigeki Suzuki, Manabu Mochizuki, Takao Shimizu, Ung-il Chung, Nobuo Sasaki |
Abstract |
Subarachnoid hemorrhage (SAH) frequently results in several complications, including cerebral vasospasm, associated with high mortality. Although cerebral vasospasm is a major cause of brain damages after SAH, other factors such as inflammatory responses and oxidative stress also contribute to high mortality after SAH. Trehalose is a non-reducing disaccharide in which two glucose units are linked by α,α-1,1-glycosidic bond, and has been shown to induce tolerance to a variety of stressors in numerous organisms. In the present study, we investigated the effect of trehalose on cerebral vasospasm, inflammatory responses, and oxidative stress induced by blood in vitro and in vivo. |
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