Title |
Assessing the effectiveness of ‘pulse radiofrequency treatment of dorsal root ganglion’ in patients with chronic lumbar radicular pain: study protocol for a randomized control trial
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Published in |
Trials, April 2012
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DOI | 10.1186/1745-6215-13-52 |
Pubmed ID | |
Authors |
Harsha Shanthanna, Philip Chan, James McChesney, James Paul, Lehana Thabane |
Abstract |
Chronic lumbar radicular pain can be described as neuropathic pain along the distribution of a particular nerve root. The dorsal root ganglion has been implicated in its pathogenesis by giving rise to abnormal impulse generation as a result of irritation, direct compression and sensitization. Chronic lumbar radicular pain is commonly treated with medications, physiotherapy and epidural steroid injections. Epidural steroid injections are associated with several common and rarer side effects such as spinal cord infarction and death. It is essential and advantageous to look for alternate interventions which could be effective with fewer side effects. Pulse radio frequency is a relatively new technique and is less destructive then conventional radiofrequency. Safety and effectiveness of pulse radio frequency in neuropathic pain has been demonstrated in animal and humans studies. Although its effects on dorsal root ganglion have been studied in animals there is only one randomized control trial in literature demonstrating its effectiveness in cervical radicular pain and none in lumbar radicular pain. Our primary objective is to study the feasibility of a larger trial in terms of recruitment and methodology. Secondary objectives are to compare the treatment effects and side effects. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 98 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 13 | 13% |
Student > Master | 12 | 12% |
Student > Ph. D. Student | 10 | 10% |
Other | 10 | 10% |
Researcher | 9 | 9% |
Other | 18 | 18% |
Unknown | 28 | 28% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 39 | 39% |
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Neuroscience | 4 | 4% |
Sports and Recreations | 2 | 2% |
Biochemistry, Genetics and Molecular Biology | 2 | 2% |
Other | 8 | 8% |
Unknown | 32 | 32% |