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Mendeley readers
Attention Score in Context
| Title |
Epigenetics of renal cell carcinoma: the path towards new diagnostics and therapeutics
|
|---|---|
| Published in |
Genome Medicine, September 2010
|
| DOI | 10.1186/gm180 |
| Pubmed ID | |
| Authors |
Mark R Morris, Eamonn R Maher |
| Abstract |
Aberrant DNA methylation, in particular promoter hypermethylation and transcriptional silencing of tumor suppressor genes, has an important role in the development of many human cancers, including renal cell carcinoma (RCC). Indeed, apart from mutations in the well studied von Hippel-Lindau gene (VHL), the mutation frequency rates of known tumor suppressor genes in RCC are generally low, but the number of genes found to show frequent inactivation by promoter methylation in RCC continues to grow. Here, we review the genes identified as epigenetically silenced in RCC and their relationship to pathways of tumor development. Increased understanding of RCC epigenetics provides new insights into the molecular pathogenesis of RCC and opportunities for developing novel strategies for the diagnosis, prognosis and management of RCC. |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 22% |
| Student > Master | 6 | 16% |
| Researcher | 5 | 14% |
| Student > Doctoral Student | 4 | 11% |
| Other | 4 | 11% |
| Other | 7 | 19% |
| Unknown | 3 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 32% |
| Agricultural and Biological Sciences | 11 | 30% |
| Biochemistry, Genetics and Molecular Biology | 9 | 24% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Unknown | 4 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2012.
All research outputs
#2,484,624
of 25,374,647 outputs
Outputs from Genome Medicine
#564
of 1,585 outputs
Outputs of similar age
#9,336
of 104,291 outputs
Outputs of similar age from Genome Medicine
#2
of 12 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,585 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.8. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,291 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.