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Osteoblast-secreted collagen upregulates paracrine Sonic hedgehog signaling by prostate cancer cells and enhances osteoblast differentiation

Overview of attention for article published in Molecular Cancer, May 2012
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2 X users

Citations

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23 Dimensions

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39 Mendeley
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Title
Osteoblast-secreted collagen upregulates paracrine Sonic hedgehog signaling by prostate cancer cells and enhances osteoblast differentiation
Published in
Molecular Cancer, May 2012
DOI 10.1186/1476-4598-11-30
Pubmed ID
Authors

Samantha M Zunich, Maria Valdovinos, Taneka Douglas, David Walterhouse, Philip Iannaccone, Marilyn L G Lamm

Abstract

Induction of osteoblast differentiation by paracrine Sonic hedgehog (Shh) signaling may be a mechanism through which Shh-expressing prostate cancer cells initiate changes in the bone microenvironment and promote metastases. A hallmark of osteoblast differentiation is the formation of matrix whose predominant protein is type 1 collagen. We investigated the formation of a collagen matrix by osteoblasts cultured with prostate cancer cells, and its effects on interactions between prostate cancer cells and osteoblasts.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 3%
Unknown 38 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 31%
Researcher 11 28%
Student > Doctoral Student 3 8%
Student > Bachelor 2 5%
Student > Master 2 5%
Other 3 8%
Unknown 6 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 51%
Mathematics 2 5%
Engineering 2 5%
Medicine and Dentistry 2 5%
Nursing and Health Professions 1 3%
Other 4 10%
Unknown 8 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2012.
All research outputs
#14,143,926
of 22,664,644 outputs
Outputs from Molecular Cancer
#899
of 1,713 outputs
Outputs of similar age
#96,374
of 163,497 outputs
Outputs of similar age from Molecular Cancer
#8
of 15 outputs
Altmetric has tracked 22,664,644 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,713 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,497 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.