Title |
Transposable elements in the mammalian embryo: pioneers surviving through stealth and service
|
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Published in |
Genome Biology, May 2016
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DOI | 10.1186/s13059-016-0965-5 |
Pubmed ID | |
Authors |
Patricia Gerdes, Sandra R. Richardson, Dixie L. Mager, Geoffrey J. Faulkner |
Abstract |
Transposable elements (TEs) are notable drivers of genetic innovation. Over evolutionary time, TE insertions can supply new promoter, enhancer, and insulator elements to protein-coding genes and establish novel, species-specific gene regulatory networks. Conversely, ongoing TE-driven insertional mutagenesis, nonhomologous recombination, and other potentially deleterious processes can cause sporadic disease by disrupting genome integrity or inducing abrupt gene expression changes. Here, we discuss recent evidence suggesting that TEs may contribute regulatory innovation to mammalian embryonic and pluripotent states as a means to ward off complete repression by their host genome. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 33% |
United Kingdom | 2 | 11% |
South Africa | 1 | 6% |
Spain | 1 | 6% |
Brazil | 1 | 6% |
Unknown | 7 | 39% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 10 | 56% |
Members of the public | 7 | 39% |
Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Spain | 2 | <1% |
Austria | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
Brazil | 1 | <1% |
United Kingdom | 1 | <1% |
China | 1 | <1% |
Unknown | 227 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 52 | 22% |
Researcher | 34 | 14% |
Student > Master | 30 | 13% |
Student > Bachelor | 29 | 12% |
Student > Postgraduate | 10 | 4% |
Other | 31 | 13% |
Unknown | 50 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 96 | 41% |
Agricultural and Biological Sciences | 64 | 27% |
Immunology and Microbiology | 6 | 3% |
Medicine and Dentistry | 6 | 3% |
Engineering | 3 | 1% |
Other | 6 | 3% |
Unknown | 55 | 23% |