Title |
Inferring high-confidence human protein-protein interactions
|
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Published in |
BMC Bioinformatics, May 2012
|
DOI | 10.1186/1471-2105-13-79 |
Pubmed ID | |
Authors |
Xueping Yu, Anders Wallqvist, Jaques Reifman |
Abstract |
As numerous experimental factors drive the acquisition, identification, and interpretation of protein-protein interactions (PPIs), aggregated assemblies of human PPI data invariably contain experiment-dependent noise. Ascertaining the reliability of PPIs collected from these diverse studies and scoring them to infer high-confidence networks is a non-trivial task. Moreover, a large number of PPIs share the same number of reported occurrences, making it impossible to distinguish the reliability of these PPIs and rank-order them. For example, for the data analyzed here, we found that the majority (>83%) of currently available human PPIs have been reported only once. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 4% |
United States | 2 | 3% |
Brazil | 2 | 3% |
Germany | 1 | 1% |
Italy | 1 | 1% |
Ireland | 1 | 1% |
Switzerland | 1 | 1% |
India | 1 | 1% |
Malaysia | 1 | 1% |
Other | 2 | 3% |
Unknown | 56 | 79% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 32 | 45% |
Student > Ph. D. Student | 16 | 23% |
Professor > Associate Professor | 5 | 7% |
Student > Bachelor | 4 | 6% |
Student > Master | 4 | 6% |
Other | 9 | 13% |
Unknown | 1 | 1% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 42 | 59% |
Biochemistry, Genetics and Molecular Biology | 9 | 13% |
Computer Science | 9 | 13% |
Medicine and Dentistry | 4 | 6% |
Engineering | 2 | 3% |
Other | 2 | 3% |
Unknown | 3 | 4% |