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Mendeley readers
| Title |
High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity
|
|---|---|
| Published in |
BMC Gastroenterology, May 2012
|
| DOI | 10.1186/1471-230x-12-45 |
| Pubmed ID | |
| Authors |
Runkuan Yang, Shutian Zhang, Antonella Cotoia, Niku Oksala, Shengtao Zhu, Jyrki Tenhunen |
| Abstract |
Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Necrotic tissue releases high mobility group B1 (HMGB1), and HMGB1 contributes to liver injury. Even though blockade of HMGB1 does not protect against APAP-induced acute liver injury (ALI) at 9 h time point, the later time points are not studied and the role of HMGB1 in APAP overdose is unknown, it is possible that neutralization of HMGB1 might improve hepatocyte regeneration. This study aims to test whether blockade of HMGB1 improves hepatocyte regeneration after APAP overdose. |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Belgium | 1 | 3% |
| Unknown | 35 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 24% |
| Student > Ph. D. Student | 3 | 8% |
| Professor | 3 | 8% |
| Student > Bachelor | 3 | 8% |
| Student > Master | 3 | 8% |
| Other | 8 | 22% |
| Unknown | 8 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 43% |
| Agricultural and Biological Sciences | 5 | 14% |
| Immunology and Microbiology | 2 | 5% |
| Computer Science | 1 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 10 | 27% |