Title |
OPERA-LG: efficient and exact scaffolding of large, repeat-rich eukaryotic genomes with performance guarantees
|
---|---|
Published in |
Genome Biology, May 2016
|
DOI | 10.1186/s13059-016-0951-y |
Pubmed ID | |
Authors |
Song Gao, Denis Bertrand, Burton K. H. Chia, Niranjan Nagarajan |
Abstract |
The assembly of large, repeat-rich eukaryotic genomes represents a significant challenge in genomics. While long-read technologies have made the high-quality assembly of small, microbial genomes increasingly feasible, data generation can be expensive for larger genomes. OPERA-LG is a scalable, exact algorithm for the scaffold assembly of large, repeat-rich genomes, out-performing state-of-the-art programs for scaffold correctness and contiguity. It provides a rigorous framework for scaffolding of repetitive sequences and a systematic approach for combining data from different second-generation and third-generation sequencing technologies. OPERA-LG provides an avenue for systematic augmentation and improvement of thousands of existing draft eukaryotic genome assemblies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 11% |
Singapore | 3 | 11% |
United States | 3 | 11% |
Sweden | 2 | 7% |
Germany | 2 | 7% |
Taiwan | 1 | 4% |
Netherlands | 1 | 4% |
Norway | 1 | 4% |
Japan | 1 | 4% |
Other | 1 | 4% |
Unknown | 9 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 14 | 52% |
Members of the public | 10 | 37% |
Science communicators (journalists, bloggers, editors) | 2 | 7% |
Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Netherlands | 1 | <1% |
Norway | 1 | <1% |
Korea, Republic of | 1 | <1% |
Germany | 1 | <1% |
Singapore | 1 | <1% |
Czechia | 1 | <1% |
Japan | 1 | <1% |
China | 1 | <1% |
Other | 0 | 0% |
Unknown | 129 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 39 | 28% |
Researcher | 27 | 19% |
Student > Master | 16 | 12% |
Student > Bachelor | 10 | 7% |
Student > Doctoral Student | 6 | 4% |
Other | 14 | 10% |
Unknown | 27 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 51 | 37% |
Biochemistry, Genetics and Molecular Biology | 29 | 21% |
Computer Science | 19 | 14% |
Immunology and Microbiology | 4 | 3% |
Environmental Science | 2 | 1% |
Other | 5 | 4% |
Unknown | 29 | 21% |