Title |
The footprint of metabolism in the organization of mammalian genomes
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Published in |
BMC Genomics, May 2012
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DOI | 10.1186/1471-2164-13-174 |
Pubmed ID | |
Authors |
Luisa Berná, Ankita Chaurasia, Claudia Angelini, Concetta Federico, Salvatore Saccone, Giuseppe D'Onofrio |
Abstract |
At present five evolutionary hypotheses have been proposed to explain the great variability of the genomic GC content among and within genomes: the mutational bias, the biased gene conversion, the DNA breakpoints distribution, the thermal stability and the metabolic rate. Several studies carried out on bacteria and teleostean fish pointed towards the critical role played by the environment on the metabolic rate in shaping the base composition of genomes. In mammals the debate is still open, and evidences have been produced in favor of each evolutionary hypothesis. Human genes were assigned to three large functional categories (as well as to the corresponding functional classes) according to the KOG database: (i) information storage and processing, (ii) cellular processes and signaling, and (iii) metabolism. The classification was extended to the organisms so far analyzed performing a reciprocal Blastp and selecting the best reciprocal hit. The base composition was calculated for each sequence of the whole CDS dataset. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Israel | 1 | 3% |
United States | 1 | 3% |
Germany | 1 | 3% |
Unknown | 34 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 27% |
Student > Ph. D. Student | 8 | 22% |
Professor | 3 | 8% |
Student > Master | 3 | 8% |
Student > Bachelor | 2 | 5% |
Other | 4 | 11% |
Unknown | 7 | 19% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 17 | 46% |
Biochemistry, Genetics and Molecular Biology | 4 | 11% |
Mathematics | 3 | 8% |
Nursing and Health Professions | 1 | 3% |
Environmental Science | 1 | 3% |
Other | 2 | 5% |
Unknown | 9 | 24% |