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Metabolic flux profiling of recombinant protein secreting Pichia pastoris growing on glucose:methanol mixtures

Overview of attention for article published in Microbial Cell Factories, May 2012
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Title
Metabolic flux profiling of recombinant protein secreting Pichia pastoris growing on glucose:methanol mixtures
Published in
Microbial Cell Factories, May 2012
DOI 10.1186/1475-2859-11-57
Pubmed ID
Authors

Joel Jordà, Paula Jouhten, Elena Cámara, Hannu Maaheimo, Joan Albiol, Pau Ferrer

Abstract

The methylotrophic yeast Pichia pastoris has emerged as one of the most promising yeast hosts for the production of heterologous proteins. Mixed feeds of methanol and a multicarbon source instead of methanol as sole carbon source have been shown to improve product productivities and alleviate metabolic burden derived from protein production. Nevertheless, systematic quantitative studies on the relationships between the central metabolism and recombinant protein production in P. pastoris are still rather limited, particularly when growing this yeast on mixed carbon sources, thus hampering future metabolic network engineering strategies for improved protein production.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 209 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 <1%
Spain 2 <1%
Germany 1 <1%
Vietnam 1 <1%
Austria 1 <1%
Brazil 1 <1%
Chile 1 <1%
United Kingdom 1 <1%
India 1 <1%
Other 2 <1%
Unknown 196 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 56 27%
Researcher 30 14%
Student > Master 24 11%
Student > Bachelor 20 10%
Student > Postgraduate 12 6%
Other 33 16%
Unknown 34 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 67 32%
Biochemistry, Genetics and Molecular Biology 51 24%
Engineering 20 10%
Chemical Engineering 9 4%
Chemistry 6 3%
Other 14 7%
Unknown 42 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2012.
All research outputs
#15,243,549
of 22,665,794 outputs
Outputs from Microbial Cell Factories
#973
of 1,581 outputs
Outputs of similar age
#104,218
of 163,481 outputs
Outputs of similar age from Microbial Cell Factories
#19
of 22 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,581 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
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We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.