Title |
Quantitative molecular assessment of chimerism across tissues in marmosets and tamarins
|
---|---|
Published in |
BMC Genomics, March 2012
|
DOI | 10.1186/1471-2164-13-98 |
Pubmed ID | |
Authors |
Carolyn G Sweeney, Elizabeth Curran, Susan V Westmoreland, Keith G Mansfield, Eric J Vallender |
Abstract |
Marmosets are playing an increasingly large and important role in biomedical research. They share genetic, anatomical, and physiological similarities with humans and other primate model species, but their smaller sizes, reproductive efficiency, and amenability to genetic manipulation offer an added practicality. While their unique biology can be exploited to provide insights into disease and function, it is also important that researchers are aware of the differences that exist between marmosets and other species. The New World monkey family Callitrichidae, containing both marmoset and tamarin species, typically produces dizygotic twins that show chimerism in the blood and other cells from the hematopoietic lineage. Recently, a study extended these findings to identify chimerism in many tissues, including somatic tissues from other lineages and germ cells. This has raised the intriguing possibility that chimerism may play an increasingly pervasive role in marmoset biology, ranging from natural behavioral implications to increased variability and complexity in biomedical studies. |
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