Title |
Evaluation of a genetically modified foot-and-mouth disease virus vaccine candidate generated by reverse genetics
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Published in |
BMC Veterinary Research, May 2012
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DOI | 10.1186/1746-6148-8-57 |
Pubmed ID | |
Authors |
Pinghua Li, Xingwen Bai, Pu Sun, Dong Li, Zengjun Lu, Yimei Cao, Yuanfang Fu, Huifang Bao, Yingli Chen, Baoxia Xie, Zaixin Liu |
Abstract |
Foot-and-mouth disease (FMD) is the most economically important and highly contagious disease of cloven-hoofed animals worldwide. Control of the disease has been mainly based on large-scale vaccinations with whole-virus inactivated vaccines. In recent years, a series of outbreaks of type O FMD occurred in China (including Chinese Taipei, Chinese Hong Kong) posed a tremendous threat to Chinese animal husbandry. Its causative agent, type O FMDV, has evolved into three topotypes (East-South Asia (ME-SA), Southeast Asia (SEA), Cathay (CHY)) in these regions, which represents an important obstacle to disease control. The available FMD vaccine in China shows generally good protection against ME-SA and SEA topotype viruses infection, but affords insufficient protection against some variants of the CHY topotype. Therefore, the choice of a new vaccine strain is of fundamental importance. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 2 | 4% |
Indonesia | 1 | 2% |
United Kingdom | 1 | 2% |
Australia | 1 | 2% |
Unknown | 47 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 29% |
Researcher | 11 | 21% |
Student > Master | 4 | 8% |
Student > Doctoral Student | 2 | 4% |
Student > Bachelor | 2 | 4% |
Other | 7 | 13% |
Unknown | 11 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 33% |
Immunology and Microbiology | 4 | 8% |
Social Sciences | 4 | 8% |
Medicine and Dentistry | 4 | 8% |
Veterinary Science and Veterinary Medicine | 3 | 6% |
Other | 8 | 15% |
Unknown | 12 | 23% |