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X Demographics
Mendeley readers
Attention Score in Context
| Title |
HER2 heterogeneity and resistance to anti-HER2 antibody-drug conjugates
|
|---|---|
| Published in |
Breast Cancer Research, January 2020
|
| DOI | 10.1186/s13058-020-1252-7 |
| Pubmed ID | |
| Authors |
Alberto Ocaña, Eitan Amir, Atanasio Pandiella |
| Abstract |
There has been substantial interest in HER2 intratumoral heterogeneity as an explanation for the development of resistance to anti-HER2 therapies in breast cancer, particularly to trastuzumab emtansine (T-DM1). Through a literature-based approach, we discuss mechanisms of resistance to HER2-targeting antibody-drug conjugates (ADCs) in breast cancer. We describe results from clinical studies reporting the effect of anti-HER2 strategies particularly ADCs and their mechanistic effect. We review biological findings underlying HER2 heterogeneity and its implication in the development of novel anti-HER2 drugs including new ADCs in clinical development like trastuzumab deruxtecan (DS-8201). We suggest potential mechanisms to optimize these compounds and their future clinical implementation. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 14% |
| Italy | 1 | 14% |
| Germany | 1 | 14% |
| Unknown | 4 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Scientists | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 116 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 13% |
| Researcher | 15 | 13% |
| Student > Bachelor | 10 | 9% |
| Other | 7 | 6% |
| Student > Master | 7 | 6% |
| Other | 19 | 16% |
| Unknown | 43 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 13% |
| Medicine and Dentistry | 15 | 13% |
| Chemistry | 9 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Engineering | 5 | 4% |
| Other | 17 | 15% |
| Unknown | 49 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2023.
All research outputs
#6,934,435
of 25,387,668 outputs
Outputs from Breast Cancer Research
#788
of 2,054 outputs
Outputs of similar age
#141,910
of 470,550 outputs
Outputs of similar age from Breast Cancer Research
#10
of 24 outputs
Altmetric has tracked 25,387,668 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 2,054 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 470,550 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.