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Preclinical and clinical studies of estrogen deprivation support the PDGF/Abl pathway as a novel therapeutic target for overcoming endocrine resistance in breast cancer

Overview of attention for article published in Breast Cancer Research, May 2012
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Title
Preclinical and clinical studies of estrogen deprivation support the PDGF/Abl pathway as a novel therapeutic target for overcoming endocrine resistance in breast cancer
Published in
Breast Cancer Research, May 2012
DOI 10.1186/bcr3191
Pubmed ID
Authors

Marion T Weigel, Zara Ghazoui, Anita Dunbier, Sunil Pancholi, Mitch Dowsett, Lesley-Ann Martin

Abstract

The majority of breast tumors at primary diagnosis are estrogen receptor positive (ER+). Estrogen (E) mediates its effects by binding to the ER. Therapies targeting the estrogenic stimulation of tumor growth reduce mortality from ER+ breast cancer. However, resistance remains a major clinical problem.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 2%
Unknown 58 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 24%
Student > Ph. D. Student 10 17%
Student > Master 8 14%
Student > Bachelor 5 8%
Professor 3 5%
Other 8 14%
Unknown 11 19%
Readers by discipline Count As %
Medicine and Dentistry 14 24%
Agricultural and Biological Sciences 13 22%
Biochemistry, Genetics and Molecular Biology 7 12%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Nursing and Health Professions 3 5%
Other 7 12%
Unknown 11 19%