Title |
The immunosuppressive factors IL-10, TGF-β, and VEGF do not affect the antigen-presenting function of CD40-activated B cells
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Published in |
Journal of Experimental & Clinical Cancer Research, May 2012
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DOI | 10.1186/1756-9966-31-47 |
Pubmed ID | |
Authors |
Alexander Shimabukuro-Vornhagen, Andreas Draube, Tanja M Liebig, Achim Rothe, Matthias Kochanek, Michael S von Bergwelt-Baildon |
Abstract |
Progress in recent years strengthened the concept of cellular tumor vaccinations. However, a crucial barrier to successful cancer immunotherapy is tumor-mediated immunosuppression. Tumor-derived soluble factors such as IL-10, TGF-β, and VEGF suppress effector cells either directly or indirectly by disruption of dendritic cell (DC) differentiation, migration and antigen presentation. Human B cells acquire potent immunostimulatory properties when activated via CD40 and have been shown to be an alternative source of antigen-presenting cells (APCs) for cellular cancer vaccines. Nevertheless, in contrast to DCs little knowledge exists about their susceptibility to tumor derived immunosuppressive factors. Thus, we assessed whether IL-10, TGF-β, or VEGF do affect key aspects of the immunostimulatory function of human CD40-activated B cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 4% |
United States | 1 | 2% |
Unknown | 52 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 18% |
Student > Master | 8 | 15% |
Researcher | 7 | 13% |
Student > Bachelor | 5 | 9% |
Student > Doctoral Student | 4 | 7% |
Other | 9 | 16% |
Unknown | 12 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 18% |
Agricultural and Biological Sciences | 10 | 18% |
Biochemistry, Genetics and Molecular Biology | 7 | 13% |
Immunology and Microbiology | 6 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Other | 7 | 13% |
Unknown | 13 | 24% |