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Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition

Overview of attention for article published in BMC Cancer, May 2012
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

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1 X user
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7 patents

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342 Mendeley
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Title
Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition
Published in
BMC Cancer, May 2012
DOI 10.1186/1471-2407-12-178
Pubmed ID
Authors

Tobias M Gorges, Ingeborg Tinhofer, Michael Drosch, Lars Röse, Thomas M Zollner, Thomas Krahn, Oliver von Ahsen

Abstract

Circulating tumour cells (CTCs) have shown prognostic relevance in metastatic breast, prostate, colon and pancreatic cancer. For further development of CTCs as a biomarker, we compared the performance of different protocols for CTC detection in murine breast cancer xenograft models (MDA-MB-231, MDA-MB-468 and KPL-4). Blood samples were taken from tumour bearing animals (20 to 200 mm2) and analysed for CTCs using 1. an epithelial marker based enrichment method (AdnaTest), 2. an antibody independent technique, targeting human gene transcripts (qualitative PCR), and 3. an antibody-independent approach, targeting human DNA-sequences (quantitative PCR). Further, gene expression changes associated with epithelial-to-mesenchymal transition (EMT) were determined with an EMT-specific PCR assay.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 342 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 1%
Germany 3 <1%
Netherlands 1 <1%
France 1 <1%
Italy 1 <1%
Malaysia 1 <1%
Saudi Arabia 1 <1%
Sweden 1 <1%
Romania 1 <1%
Other 1 <1%
Unknown 326 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 82 24%
Researcher 61 18%
Student > Master 39 11%
Student > Bachelor 33 10%
Student > Doctoral Student 21 6%
Other 44 13%
Unknown 62 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 63 18%
Medicine and Dentistry 62 18%
Biochemistry, Genetics and Molecular Biology 53 15%
Engineering 35 10%
Chemistry 19 6%
Other 31 9%
Unknown 79 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2023.
All research outputs
#3,072,994
of 23,575,882 outputs
Outputs from BMC Cancer
#681
of 8,482 outputs
Outputs of similar age
#20,152
of 165,209 outputs
Outputs of similar age from BMC Cancer
#5
of 65 outputs
Altmetric has tracked 23,575,882 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,482 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,209 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.