Title |
Altered tryptophan and alanine transport in fibroblasts from boys with attention-deficit/hyperactivity disorder (ADHD): an in vitro study
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Published in |
Behavioral and Brain Functions, September 2011
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DOI | 10.1186/1744-9081-7-40 |
Pubmed ID | |
Authors |
Jessica Johansson, Magnus Landgren, Elisabeth Fernell, Ravi Vumma, Arne Åhlin, Lars Bjerkenstedt, Nikolaos Venizelos |
Abstract |
The catecholaminergic and serotonergic neurotransmitter systems are implicated in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD). The amino acid tyrosine is the precursor for synthesis of the catecholamines dopamine and norepinephrine, while tryptophan is the precursor of serotonin. A disturbed transport of tyrosine, as well as other amino acids, has been found in a number of other psychiatric disorders, such as schizophrenia, bipolar disorder and autism, when using the fibroblast cell model. Hence, the aim of this study was to explore whether children with ADHD may have disturbed amino acid transport. |
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