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Dual role of autophagy in HIV-1 replication and pathogenesis

Overview of attention for article published in AIDS Research and Therapy, January 2012
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  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

twitter
3 tweeters
video
1 video uploader

Citations

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51 Dimensions

Readers on

mendeley
63 Mendeley
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Title
Dual role of autophagy in HIV-1 replication and pathogenesis
Published in
AIDS Research and Therapy, January 2012
DOI 10.1186/1742-6405-9-16
Pubmed ID
Authors

M Killian

Abstract

Autophagy, the major mechanism for degrading long-lived intracellular proteins and organelles, is essential for eukaryotic cell homeostasis. Autophagy also defends the cell against invasion by microorganisms and has important roles in innate and adaptive immunity. Increasingly evident is that HIV-1 replication is dependent on select components of autophagy. Fittingly, HIV-1 proteins are able to modulate autophagy to maximize virus production. At the same time, HIV-1 proteins appear to disrupt autophagy in uninfected cells, thereby contributing to CD4+ cell death and HIV-1 pathogenesis. These observations allow for new approaches for the treatment and possibly the prevention of HIV-1 infection. This review focuses on the relationship between autophagy and HIV-1 infection. Discussed is how autophagy plays dual roles in HIV-1 replication and HIV-1 disease progression.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Norway 1 2%
Canada 1 2%
Unknown 60 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 29%
Researcher 10 16%
Student > Master 9 14%
Student > Bachelor 7 11%
Student > Doctoral Student 4 6%
Other 9 14%
Unknown 6 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 40%
Biochemistry, Genetics and Molecular Biology 13 21%
Immunology and Microbiology 7 11%
Medicine and Dentistry 5 8%
Neuroscience 2 3%
Other 5 8%
Unknown 6 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2016.
All research outputs
#9,989,757
of 17,355,315 outputs
Outputs from AIDS Research and Therapy
#241
of 435 outputs
Outputs of similar age
#69,423
of 132,816 outputs
Outputs of similar age from AIDS Research and Therapy
#2
of 8 outputs
Altmetric has tracked 17,355,315 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 435 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 132,816 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.