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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Dual role of autophagy in HIV-1 replication and pathogenesis
|
|---|---|
| Published in |
AIDS Research and Therapy, May 2012
|
| DOI | 10.1186/1742-6405-9-16 |
| Pubmed ID | |
| Authors |
M Scott Killian |
| Abstract |
Autophagy, the major mechanism for degrading long-lived intracellular proteins and organelles, is essential for eukaryotic cell homeostasis. Autophagy also defends the cell against invasion by microorganisms and has important roles in innate and adaptive immunity. Increasingly evident is that HIV-1 replication is dependent on select components of autophagy. Fittingly, HIV-1 proteins are able to modulate autophagy to maximize virus production. At the same time, HIV-1 proteins appear to disrupt autophagy in uninfected cells, thereby contributing to CD4+ cell death and HIV-1 pathogenesis. These observations allow for new approaches for the treatment and possibly the prevention of HIV-1 infection. This review focuses on the relationship between autophagy and HIV-1 infection. Discussed is how autophagy plays dual roles in HIV-1 replication and HIV-1 disease progression. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Norway | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 75 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 23% |
| Researcher | 10 | 13% |
| Student > Master | 9 | 12% |
| Student > Bachelor | 9 | 12% |
| Student > Doctoral Student | 4 | 5% |
| Other | 10 | 13% |
| Unknown | 18 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 32% |
| Biochemistry, Genetics and Molecular Biology | 13 | 17% |
| Medicine and Dentistry | 8 | 10% |
| Immunology and Microbiology | 7 | 9% |
| Neuroscience | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 17 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2016.
All research outputs
#15,982,037
of 25,371,288 outputs
Outputs from AIDS Research and Therapy
#338
of 637 outputs
Outputs of similar age
#106,571
of 176,182 outputs
Outputs of similar age from AIDS Research and Therapy
#2
of 8 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 637 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,182 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.