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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Electronic cigarette exposure triggers neutrophil inflammatory responses
|
|---|---|
| Published in |
Respiratory Research, May 2016
|
| DOI | 10.1186/s12931-016-0368-x |
| Pubmed ID | |
| Authors |
Andrew Higham, Nicholas J. W. Rattray, Jennifer A. Dewhurst, Drupad K. Trivedi, Stephen J. Fowler, Royston Goodacre, Dave Singh |
| Abstract |
The use of electronic cigarettes (e-cigs) is increasing and there is widespread perception that e-cigs are safe. E-cigs contain harmful chemicals; more research is needed to evaluate the safety of e-cig use. Our aim was to investigate the effects of e-cigs on the inflammatory response of human neutrophils. Neutrophils were exposed to e-cig vapour extract (ECVE) and the expression of CD11b and CD66b was measured by flow cytometry and MMP-9 and CXCL8 by ELISA. We also measured the activity of neutrophil elastase (NE) and MMP-9, along with the activation of inflammatory signalling pathways. Finally we analysed the biochemical composition of ECVE by ultra-high performance liquid chromatography mass spectrometry. ECVE caused an increase in the expression of CD11b and CD66b, and increased the release of MMP-9 and CXCL8. Furthermore, there was an increase in NE and MMP-9 activity and an increase in p38 MAPK activation. We also identified several harmful chemicals in ECVE, including known carcinogens. ECVE causes a pro-inflammatory response from human neutrophils. This raises concerns over the safety of e-cig use. |
X Demographics
The data shown below were collected from the profiles of 106 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 19 | 18% |
| United States | 10 | 9% |
| Australia | 8 | 8% |
| Netherlands | 3 | 3% |
| New Zealand | 3 | 3% |
| Canada | 2 | 2% |
| France | 2 | 2% |
| Bosnia and Herzegovina | 1 | <1% |
| Jamaica | 1 | <1% |
| Other | 8 | 8% |
| Unknown | 49 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 83 | 78% |
| Scientists | 14 | 13% |
| Practitioners (doctors, other healthcare professionals) | 5 | 5% |
| Science communicators (journalists, bloggers, editors) | 4 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| United States | 1 | <1% |
| Unknown | 170 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 30 | 17% |
| Researcher | 20 | 12% |
| Student > Ph. D. Student | 14 | 8% |
| Student > Master | 13 | 8% |
| Other | 9 | 5% |
| Other | 30 | 17% |
| Unknown | 57 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 42 | 24% |
| Biochemistry, Genetics and Molecular Biology | 15 | 9% |
| Agricultural and Biological Sciences | 11 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 5% |
| Environmental Science | 7 | 4% |
| Other | 27 | 16% |
| Unknown | 63 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 152. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2023.
All research outputs
#270,737
of 25,373,627 outputs
Outputs from Respiratory Research
#25
of 3,062 outputs
Outputs of similar age
#5,251
of 342,339 outputs
Outputs of similar age from Respiratory Research
#1
of 41 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,062 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,339 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.