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Mendeley readers
| Title |
Heterozygous β-thalassaemia as a susceptibility factor in mood disorders: excessive prevalence in bipolar patients
|
|---|---|
| Published in |
Clinical Practice and Epidemiology in Mental Health, June 2005
|
| DOI | 10.1186/1745-0179-1-6 |
| Pubmed ID | |
| Authors |
Alberto Bocchetta |
| Abstract |
BACKGROUND: Previous preliminary reports have suggested potential interactions between microcytic anaemia and mood disorders. In particular, heterozygous beta-thalassaemia has been implicated in the bipolar spectrum. This study surveyed relevant haematological parameters in a large sample of psychiatric outpatients with the aim of clarifying previous observations. METHODS: Mean Corpuscular Volume (MCV) was analysed in 1014 consecutive patients diagnosed according to modified Research Diagnostic Criteria (RDC). Haemoglobin electrophoresis and/or chromatography was performed in blood samples from 143 patients with reduced MCV. Prevalence of heterozygous beta-thalassaemia was estimated based on the rates of patients with reduced MCV and increased haemoglobin A2 concentration. RESULTS: MCV lower than 80 mu3 was found in greater proportions among bipolar compared with the remaining RDC subgroups (183/732 = 25.0% versus 51/282 = 18.1%; p = 0.02; relative risk = 1.38; Fisher's exact test). This difference can mainly be attributed to heterozygous beta-thalassaemia, the estimated prevalence of which was 16.4% among bipolar and 9.9% among non-bipolar subgroups (p = 0.01; relative risk = 1.65). CONCLUSION: The results are consistent with the hypothesis that heterozygous beta-thalassaemia might play a role as a susceptibility factor in bipolar spectrum disorders in specific populations. |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 13% |
| Tunisia | 1 | 13% |
| Unknown | 6 | 75% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 2 | 25% |
| Professor > Associate Professor | 2 | 25% |
| Student > Ph. D. Student | 1 | 13% |
| Other | 1 | 13% |
| Researcher | 1 | 13% |
| Other | 1 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 50% |
| Nursing and Health Professions | 1 | 13% |
| Social Sciences | 1 | 13% |
| Agricultural and Biological Sciences | 1 | 13% |
| Unknown | 1 | 13% |