Title |
Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases
|
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Published in |
Stem Cell Research & Therapy, May 2016
|
DOI | 10.1186/s13287-016-0330-3 |
Pubmed ID | |
Authors |
Yini Wang, Xiaopeng Yu, Ermei Chen, Lanuan Li |
Abstract |
Mesenchymal stem cells (MSCs) represent an attractive cell type for research and therapy due to their ability to proliferate, differentiate, modulate immune reactions, and secrete trophic factors. MSCs exist in a multitude of tissues, including bone marrow, umbilical cord, and adipose tissues. Moreover, MSCs have recently been isolated from the liver. Compared with other MSC types, liver-derived human MSCs (LHMSCs) possess general morphologies, immune functions, and differentiation capacities. Interestingly, LHMCSs produce higher levels of pro-angiogenic, anti-inflammatory, and anti-apoptotic cytokines than those of bone marrow-derived MSCs. Thus, these cells may be a promising therapeutic source for liver diseases. This paper summarizes the biological characteristics of LHMSCs and their potential benefits and risks for the treatment of liver diseases. |
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
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Demographic breakdown
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Student > Master | 18 | 17% |
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Researcher | 11 | 11% |
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